![]() Results To date, ITACS has enrolled 615 patients in 30 hospitals in 9 countries. The primary endpoint is the number of days alive and at home up to 90 days after surgery. The patients, health care providers, data collectors, and statistician are blinded to whether patients receive IV iron 1,000 mg, or placebo, at 1-26 weeks before their planned date of surgery. Methods ITACS is a 1,000 patient, international randomized trial in patients with anemia undergoing elective cardiac surgery. We have initiated the intravenous iron for treatment of anemia before cardiac surgery (ITACS) Trial to test the hypothesis that in patients with anemia awaiting elective cardiac surgery, IV iron will reduce complications, and facilitate recovery after surgery. Iron deficiency is the commonest cause of anemia and preoperative intravenous (IV) iron therapy thus may improve anemia and therefore patient outcome following cardiac surgery. Anemia increases the likelihood of requiring a red cell transfusion and is associated with increased complications, intensive care, and hospital stay following surgery. 11 Department of Anesthesia and Pain Medicine, University of Toronto, Toronto, Ontario, Canada.īackground Approximately 20% to 30% of patients awaiting cardiac surgery are anemic.10 Cardiothoracic Quality and Outcomes, SALHN Perfusion Service, Flinders Medical Centre and Flinders University, Adelaide, South Australia, Australia.9 Department of Anaesthesiology and Perioperative Medicine, Alfred Hospital, Melbourne, Victoria, Australia Department of Anaesthesiology and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia.8 Deakin Health Economics, Institute for Health Transformation, Faculty of Health, Deakin University, Burwood, Victoria, Australia.7 Department of Cardiothoracic Surgery, Alfred Hospital, Melbourne, Victoria, Australia.6 School of Public Health and Preventive Medicine, Monash University Melbourne, Victoria, Australia.5 Department of Clinical Haematology, Monash Health and University, Clayton, Victoria, Australia School of Public Health and Preventive Medicine, Monash University Melbourne, Victoria, Australia.4 Department of Cardiothoracic Surgery, Monash Health, Clayton, Victoria, Australia Department of Surgery, Monash University, Clayton, Victoria, Australia.3 Department of Anaesthesiology and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia Department of Anaesthesia and Intensive Care, Royal Papworth Hospital, Cambridge, United Kingdom.Electronic address: 2 Department of Anaesthesiology and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia Department of Surgery, University of Western Australia, Perth, Western Australia, Australia. ![]() 1 Department of Anaesthesiology and Perioperative Medicine, Alfred Hospital, Melbourne, Victoria, Australia Department of Anaesthesiology and Perioperative Medicine, Monash University, Melbourne, Victoria, Australia.
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